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Abstract #3630

Contribution of basal forebrain damage to cognitive deficits in Parkinson’s disease

Fatma Gargouri1,2, Cécile Gallea1,2,3, Marie Mongin1,2,3, Nadya Pyatigorskaya1,2,3,4, Romain Valabregue1,2, Marie Sarazin5, Lydia Yahia-Cherif1,2, Marie Vidailhet2,3,6, and Stéphane Lehéricy1,2,3,4

1Institut du Cerveau et de la Moelle épinière – ICM, Centre de NeuroImagerie de Recherche – CENIR, Paris, France, 2Sorbonne Universités, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, Paris, France, 3ICM Team Control of Normal and Abnormal Movement, Paris, France, 4Service de neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France, 5Service de Neurologie, Hôpital Saint Anne, Paris, France, 6Département de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France

We investigated the contribution of basal forebrain damage in the cognitive dysfunction of 52 non-demented patients with Parkinson’s disease (PD) and 25 age-matched healthy controls using diffusion and resting state functional MRI. Patients showed diffusion changes in the basal forebrain and the fornix. They also showed reduced functional connectivity between the septal area and the temporal lobe including the hippocampi and parahippocampal gyri, and between the basal nucleus of Meynert and frontal areas and bilateral thalami. Structural and functional changes correlated with memory and executive functions.

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