Abstract #3574

Feasibility of Imaging Lung Cancer Using Hyperpolarized MRI Technology

Mehrdad Pourfathi¹, Luis Loza¹, Stephen Kadlecek¹, Ian Duncan¹, Diane Lim², Shampa Chatterjee³, Kai Ruppert¹, Sarmad Siddiqui¹, Harrilla Profka¹, Yan Liu², Jessica Kim², Hooman Hamedani¹, Yi Xin¹, Faraz Amzajerdian¹, Maurizio Cereda⁴, Ryan Baron¹, Mary Spencer¹, Tahmina Achekzai¹, Jose Conejo-Garcia⁵, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Sleep Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Physiology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, ⁵Moffitt Cancer Center, Tampa, FL, United States

We demonstrate the feasibility of hyperpolarized MRI technology to image lung cancer in mice. We demonstrated the use of ¹³C MRSI to detect elevated pyruvate to lactate conversion in the tumor relative to the adjacent non-cancerous lung tissue. We also showed the feasibility of ¹²⁹Xe imaging to detect non-aerated regions in the lung tissue co-localized with the tumor. The utility of these modalities combined may provide a multi-faceted tool to assess tumor's stage and its response to therapy in lung cancer.

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