Abstract #3562

Improving robustness of hyperpolarized 13C MRSI using k-t spiral acquisitions

Erin Adamson¹, Benjamin Cox^1,2,3, and Sean Fain^1,4,5

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Morgridge Institute for Research, Madison, WI, United States, ³Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI, United States, ⁴Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁵Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Hyperpolarized ¹³C MRSI with chemical shift encoding relies on a priori knowledge of the N ¹³C-labeled metabolite resonances and N+1 echoes to fully determine the reconstruction. However, the a priori frequencies may shift due to B₀ inhomogeneity, local susceptibilities, or motion, causing spectral leakage, blurring, and biased quantitative measures. To address these uncertainties, we apply IDEAL-based k-t spiral imaging with field-of-view oversampling to further constrain the signal model-based reconstruction in situations where the echo-spacing may be suboptimal, and we test the results in digital simulations, phantom experiments, and in vivo studies of murine renal metabolism. Results support improved metabolic quantification.

This abstract and the presentation materials are available to members only; a login is required.

Join Here