Abstract #3560

Multichannel Hyperpolarized 13C MRI in a Patient with Liver Metastases using Multi-slice EPI and an Alternating Projection Method for Denoising

Rie B Hansen¹, Jeremy W Gordon², Peter J Shin², Zihan Zhu^2,3, Daniele Mammoli², Pamela N Munster⁴, Rahul Aggarwal⁴, Michael A Ohliger², Peder EZ Larson², Lars G Hanson¹, Jan H Ardenkjær-Larsen¹, and Daniel B Vigneron²

¹Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark, ²Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ³UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley and UCSF, San Francisco, CA, United States, ⁴Department of Medicine, UCSF, San Francisco, CA, United States

Hyperpolarized ¹³C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human ¹³C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness, and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.

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