Abstract #3478

DCE-MRI of Intracranial Artery Athoersclerosis: Quantitative Change After 6-month Statin Therapy.

Huijun Chen¹, Jiaqi Dou¹, Le He¹, Chunyao Wang¹, Haikun Qi¹, Qiang Zhang¹, and Xihai Zhao¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua university, Beijing, China

Dynamic contrast-enhanced MRI (DCE-MRI) has been proven to be able to quantify the inflammation and neovasculature in the atherosclerotic plaque of carotid artery. However, few studies has focus on the DCE-MRI of intracranial artery atherosclerosis, which is another major cause of cerebral ischemic events. This study found that the K^trans of intracranial artery calculated from DCE-MRI was significantly lower at follow-up comparing with baseline after 6-month statin therapy, suggesting DCE-MRI a good tool for therapeutic response evaluation for intracranial artery atherosclerosis

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