Abstract #3472

A Phantom Study to Compare the Theoretical Accuracy and Precision of CT Angiography versus Radial MRI for the Assessment of Coronary Endothelial Function

Jerome Yerly^1,2, Fabio Becce¹, Danilo Gubian³, Ruud van Heeswijk^1,2, Francis R Verdun⁴, Reto Meuli¹, and Matthias Stuber^1,2

¹Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV and UNIL), Lausanne, Switzerland, ²Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ³Direction des Constructions, Ingénierie, Technique et Sécurité (CIT-S), Lausanne University Hospital (CHUV and UNIL), Lausanne, Switzerland, ⁴Institute of Radiation Physics, Lausanne University Hospital (CHUV and UNIL), Lausanne, Switzerland

CT angiography (CTA) and MRI are non-invasive imaging modalities to assess coronary endothelial function (CEF). However, the performance of these techniques has yet to be quantitatively compared. Images of an in vitro phantom that simulates a physiological range of coronary artery cross-sectional areas (CSAs) were acquired using both CTA and MRI. CSAs were automatically measured and compared to the known nominal values. Statistical analysis suggests that MRI is capable of detecting significantly smaller CSA differences than CTA (2.25±0.80% vs. 7.42±0.63% for a 3-mm baseline diameter; p<0.0001), which is well within the range of physiological vasomotor responses of proximal coronary arteries.

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