Abstract #3338

Subtle differences in left ventricular cardiotoxicity remodeling between risk groups of cancer survivors based on strain analysis from cine-DENSE MRI

Delphine Perie-Curnier¹, Denis Corbin¹, Frederik Epstein², Daniel Auger², Tarik Hafyane³, and Daniel Curnier⁴

¹Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ²Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ³Research Center, Montreal Heart Institute, Montreal, QC, Canada, ⁴Kinesiology, University of Montreal, Montreal, QC, Canada

The aim of this study was to evaluate a reliable clinical tool to assess subtle differences in left ventricular cardiotoxicity remodeling in acute lymphoblastic leukemia survivors. Cine-DENSE MRI provided accurate evaluation of heart’s functionality of young cancer survivors in the short-axis view. Significant strain differences between groups were mostly observed in basal septal and apical septal segments while most of the other segments did not show significant differences. The next step of this study will be to include a control group of healthy volunteers.

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