Abstract #3311

High-resolution neurite orientation dispersion and density imaging of mouse brain using compressed sensing at 9.4T

Nian Wang¹, Jieying Zhang², Gary Cofer¹, Robert J. Anderson¹, Yi Qi¹, and G. Allan Johnson¹

¹Center for In Vivo Microscopy, Department of Radiology, Duke University, Durham, NC, United States, ²Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China

To evaluate the potentials of compressed sensing (CS) in quantification of neurite orientation dispersion and density imaging (NODDI) index of ex vivo mouse brain at high resolution (45 µm³ isotropic). We were able to achieve compression factors of 4X through judicious choice of k-space sampling pattern. The strong heterogeneous microstructure of corpus callosum (CC) regions were illustrated using different diffusion metrics and NODDI index.

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