Abstract #3303

Probing Activated Regions in Rat’s Olfactory System by Odor Stimulations through Manganese Enhanced MRI (MEMRI) at 7T

Bin Zhang¹, Qunchen Yuan¹, Zhen Qin¹, Liujing Zhuang¹, Ping Wang^1,2, and Xiaotong Zhang^1,2

¹Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China

In vivo bioelectronic nose utilizes mammalian olfactory system as a means of odor detection and discrimination. However, electrode localization during implantation relies on the researcher’s experiences, resulting in an unreliable success rate. The goal of this research is to determine the optimal electrode implantation positions for electrophysiological recordings by using the technique of manganese enhanced MRI (MEMRI) at 7T. A small dose of manganese ion was delivered into the rat’s right naris and an odor was delivered to its nose during MRI scanning. With the MRI data, the region activated by the specific odor can be identified in the OB.

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