Abstract #3292

Test-retest reproducibility of cortical thickness, B1+, and R1 in healthy young adults measured at 7T

Koji Fujimoto¹, Yuta Urushibata², Hideto Kuribayashi², Tobias Kober^3,4,5, Tadashi Isa¹, and Tomohisa Okada¹

¹Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Siemens Healthcare K.K., Tokyo, Japan, ³Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁴Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, ⁵Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Twenty-two healthy volunteers were scanned at 7T using MP2RAGE (R1 mapping) and Sa2RAGE (B1 mapping) sequences. Applying a modified HCP pipeline, within-subject (test-retest) reproducibility and across-subject variability of cortical thickness, B1+, and R1 were analyzed. The mean absolute difference of cortical thickness was larger at the bilateral lower temporal lobes and insula. Intra-subject variation of B1+ was larger in the lower temporal lobe, whereas across-subject variation of B1+ seems to come from reference transmitter amplitude settings. Except for the lower temporal lobes, variation in the cerebral cortex R1 was very small for both intra-subject measurement (1.5%) and across-subject measurement (3%).

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