Even with its crucial role as the backbone of communication within the brain and susceptibility to damage from diseases such as stroke and multiple sclerosis, the white-matter connectional architecture of the human brain has been largely ignored. To address this, we have developed a whole-brain model for the quantification of white-matter connectional anatomy – the Tractography-based Lesion Assessment Standard (TractLAS) – which provides a complete connectional network description of the human brain. It can be used to quantify the impact of lesions on the connectivity of the brain within individuals, providing clinically useful information for individualised care.
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