The TgF344-AD rats represent the most suitable and promising animal model for Alzheimer’s disease (AD) research. Resting-state functional MRI was longitudinally acquired every 3 months in a cohort of transgenic Tg344-AD and control Fisher rats between 5 and 15 months of age, together with cognitive task evaluation. Independent component analysis was applied to rs-fMRI volumes and 10 networks were anatomically identified. Spearman correlation coefficients between functional and cognitive parameters were computed. Our results show that while no differences were observed in the cognitive task between both groups, significant differences were found in the functional networks.
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