Abstract #3254

In-vivo probabilistic structural atlas of the inferior colliculus, superior colliculus, medial geniculate nucleus, and lateral geniculate nucleus based on 7 Tesla MRI

Christian Strong¹, Nicola Toschi^2,3, Bruce Rosen², Lawrence L Wald², and Marta Bianciardi²

¹Department of Neurosurgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States, ²Department of Radiology, A.A. Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, MA, United States, ³Medical Physics Section, Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome “Tor Vergata”, Rome, Italy

Brainstem and thalamic nuclei such as the inferior-colliculus, superior-colliculus, lateral-geniculate-nucleus, and medial-geniculate-nucleus modulate visual/oculo-motor and auditory/auditory-motor functions. Dysfunction of these nuclei is implicated in disease states such as auditory-agnosia, pure-word deafness, eye-movement and visual-field deficits, Parkinson’s hallucinations, and glaucoma. However, a stereotaxic probabilistic atlas of these nuclei in humans does not exist. We used segmentation of 1.1mm-isotropic 7Tesla T₂-weighted- and diffusion-fractional-anisotropy-images to generate and validate an in-vivo probabilistic neuroimaging-based structural atlas of these nuclei in stereotaxic-MNI space. We constructed this atlas to aid the localization of these nuclei in conventional images for future research and clinical investigations of visual/auditory functions.

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