Abstract #3242

Correlation of baseline DSI based metrics with clinical motor outcomes at 6 weeks after acute ischemic stroke

Kyler K Hodgson¹, Ganesh Adluru², Lorie Richards³, Jennifer Majersik⁴, Nagesh Adluru⁵, and Edward DiBella²

¹Bioengineering, University of Utah, Salt Lake City, UT, United States, ²Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, ³Occupational Therapy, University of Utah, Salt Lake City, UT, United States, ⁴Neurology, University of Utah, Salt Lake City, UT, United States, ⁵Waisman Center, University of Wisconsin, Madison, WI, United States

The difference between the baseline ipsilesional and contralesional mean values in the internal capsule from Orientation Dispersion Index and Generalized Fractional Anisotropy correlate strongly with upper extremity clinical outcomes at 6 weeks. These models account for regions of crossing fibers and demonstrate improvements over DTI in using brain microstructure to make clinical judgments.

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