Abstract #3233

Pre-treatment intra- and inter- voxel magnetic resonance diffusion heterogeneity correlates with chemoradiotherapy treatment outcome of patients with head and neck squamous cell carcinoma

Marianthi-Vasiliki Papoutsaki¹, Harbir Singh Sidhu¹, Nikolaos Dikaios², David Atkinson¹, Timothy Beale³, Simon Morley³, Martin Forster⁴, Dawn Carnell⁵, Ruheena Mendes⁵, and Shonit Punwani¹

¹Centre of Medical Imaging, Division of Medicine, University College of London, London, United Kingdom, ²Centre for Vision, Speech and Signal Processing, University of Surrey, London, United Kingdom, ³Department of Radiology, University College Hospital, London, United Kingdom, ⁴Research Department of Oncology, University College Hospital, London, United Kingdom, ⁵Radiotherapy Department, University College Hospital, London, United Kingdom

Heterogeneity assessment and diffusion weighted magnetic resonance imaging (DW-MRI) have been considered powerful diagnostic tools in predicting chemoradiotherapy treatment outcome in patients with cancer. In this study, pre-treatment microstructural heterogeneity derived by intra- and inter-voxel MR diffusion rates was assessed in patients with neck squamous cell carcinoma (HNSCC). A correlation was presented between the pre-treatment MR diffusion heterogeneity and the chemoradiotherapy treatment outcome of patients with HNSCC. Future work, to ascertain the mechanisms of these correlations would open the opportunity to tailor therapies to individuals in clinical practice.

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