Apparent exchange rate (AXR) mapping might provide an insight into the exchange of water between intra- and extracellular space by using a double-diffusion encoded sequence with varying mixing time between the two gradient pairs. To investigate the connection between AXR and membrane permeability and to test the assumptions of the underlying theory, Monte Carlo simulations using simplified tissue models were performed. Simulations covered a broad range of membrane permeabilities to determine limits of the applicability of this technique. For the considered simplified tissue model, AXR-values could be reliably related to membrane permeabilities typically occurring in vivo.
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