Abstract #3220

Realistic 3D Fiber Crossing Phantom Models for Monte Carlo Diffusion Simulations

Jonathan Rafael-Patino¹, Gabriel Girard¹, David Romascano¹, Muhamed Barakovic¹, Gaëtan Rensonnet^2,3, Jean-Philippe Thiran^1,4, and Alessandro Daducci^1,4,5

¹Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²ICTEAM Institute, Université catholique de Louvain., Louvain-la-Neuve, Belgium, ³Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Lausanne, Switzerland, ⁴Radiology Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland, ⁵Computer Science Department, University of Verona, Verona, Italy

Monte-Carlo Diffusion Simulations has proved to be a powerful approach to study Diffusion-Weighted MRI; from generating ground-truth data, to study the diffusion process in complex media. However, a major problem with the current approaches is that they oversimplify the geometrical properties of the diffusion media. In this work we present a framework to create 3D meshes for realistic configurations that can be used for MCDS. The synthesized signals from this models can be used to study microstructure and tractography methods, which is of vital importance since novel methods require better ground-truth that mimics real tissue properties to avoid oversimplifications.

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