Abstract #3160

The impact of age and sex on mouse brain stiffness measured with Magnetic Resonance Elastography

Katharina Schregel^1,2,3, Miklos Palotai^2,3, Navid Nazari⁴, Julie Priya Merchant⁵, Walter Monroe Taylor⁵, Charles Guttmann^2,3, Ralph Sinkus⁶, Tracy Young-Pearse^3,5, and Samuel Patz^2,3

¹Institute of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany, ²Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Department of Biomedical Engineering, Boston University, Boston, MA, United States, ⁵Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, United States, ⁶Department of Radiological Imaging, Imaging Sciences & Biomedical Engineering Division, King's College London, London, United Kingdom

Aging is accompanied by neurodegeneration, which affects the cerebral biomechanical properties. We investigated the impact of age and sex on mouse brain stiffness using magnetic resonance elastography (MRE). Repeated MRI and MRE exams were performed on 5 male and 5 female healthy C57BL/6 mice over 14 months. A significant decrease of the viscoelastic modulus |G*| was observed, while the phase angle Y remained unaltered. Grey and white matter exhibited significant differences in |G*| and Y. Sex differences were observed in the cortex at 11 months. This is relevant for future cerebral MRE studies on mice.

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