Abstract #3137

Spatio-temporal features of brain's iron accumulation across the life span.

Vyacheslav Karolis^1,2, Thomas Hope³, Nikolaus Weiskopf⁴, Martina Callaghan³, Geraint Rees⁵, and Marinella Cappelletti^5,6

¹ICM - Institut du Cerveau et de la Moelle épinière, Hôpital de la Salpêtrière, Paris, France, ²Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, ³Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom, ⁴Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁵Institute of Cognitive Neuroscience, University College London, London, United Kingdom, ⁶Psychology Department, Goldsmiths College, London, United Kingdom

In this study we characterised the spatiotemporal features of age-related iron accumulation marked by R2* maps in 97 participants distributed over the whole range of ages between 20 and 75 years old. The analyses showed a broad spectrum of linear and non-linear patterns of age-related differences in R2*. These were predominantly confined to striatum, motor, pre-motor and parietal regions of grey matter as well as subgyral pre- and postcentral regions of white matter. The spatial distribution of R2* changes seems to be related to a higher prevalence of long-distance white matter connections originating from a region.

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