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Abstract #3117

Stromal collagen content correlates with fast diffusivity signal fraction in breast lesions

Liv Egnell1,2, Igor Vidić1, Dennis W. Adams, Jr.3, Neil P. Jerome2,4, Torill E. Sjøbakk4, Agnes Østlie2, Hans E. Fjøsne5,6, Rebecca Rakow-Penner7, Anders M. Dale7,8, Anna M. Bofin9, Tone F. Bathen4, and Pål Erik Goa1,2

1Department of Physics, NTNU – Norwegian University of Science and Technology, Trondheim, Norway, 2Clinic of Radiology and Nuclear Medicine, St. Olavs University Hospital, Trondheim, Norway, 3Department of Pathology, University of California San Diego School of Medicine, San Diego, CA, United States, 4Department of Circulation and Medical Imaging, NTNU – Norwegian University of Science and Technology, Trondheim, Norway, 5Department of Cancer Research and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway, 6Department of Surgery, St. Olavs University Hospital, Trondheim, Norway, 7Department of Radiology, University of California, San Diego, La Jolla, CA, United States, 8Department of Neurosciences, University of California, San Diego, La Jolla, CA, United States, 9Department of Clinical and Molecular Medicine, NTNU – Norwegian University of Science and Technology, Trondheim, Norway

The deviation from a monoexponential of the DW-signal decay towards higher b-values (>1000s/mm2) reflects the complex tissue microstructure. The biexponential decay model assumes that the signal is composed of two components with different diffusivity, possibly originating from two physically separated tissue components. In this study, we estimate the collagenous and non-collagenous extracellular contents in sixteen breast lesions using hematoxylin-eosin-saffron stained histological specimens and compare with pre-surgical in vivo DW-MRI data. Our results show that the signal fraction of the faster diffusivity component correlated significantly with collagen content, suggesting that collagen contributes to the DWI signal decay

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Abstract