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Abstract #3061

In vitro and in vivo 13C metabolic imaging of pyruvate to lactate conversion with high spatial and temporal resolution using a me-bSSFP sequence

Christoph Alexander Müller1,2, Christian Hundshammer3, Miriam Braeuer3, Jason Graham Skinner1, Adam Espe Hansen4, Sven Mansson5, Franz Schilling3, Jochen Leupold1, Dominik von Elverfeldt1, Jan Henrik Ardenkjaer-Larsen6, Markus Schwaiger3, Jürgen Hennig1, and Jan-Bernd Hövener7

1Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2German Consortium for Translational Cancer Research (DKTK), Partnersite Freiburg, German Center for Cancer Research (DKFZ), Heidelberg, Germany, 3Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, München, Germany, 4Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 5Medical Radiation Physics, Malmö University Hospital, Lund University, Malmö, Sweden, 6Department of Electrical Engineering, Technical University of Denmark, Copenhagen, Denmark, 7Section for Biomedical Imaging, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, University of Kiel, Kiel, Germany

In order to use the transient signal of hyperpolarized tracers and their metabolites efficiently, dedicated imaging sequences are required. Here, we present a multi-echo bSSFP sequence with Dixon-based iterative reconstruction to obtain metabolite maps of hyperpolarized [1‑13C]pyruvate and the product of an enzymatic conversion [1-13C]lactate on a human 3T PET-MRI system in vitro and in vivo. When comparing to other methods (i.e. CSI and non-localized NMR spectra) we found that me-bSSFP provides good metabolite separation and reliable quantitative kinetic data more than 16 times faster than CSI (350 ms vs. 5.8 s), while consuming a similar amount of hyperpolarized magnetization.

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