Abstract #3059

In vivo hyperpolarization transfer in a clinical MRI scanner

Cornelius von Morze¹, Galen D. Reed², Peder E. Larson¹, Daniele Mammoli¹, Albert P. Chen², James Tropp³, Mark Van Criekinge¹, Michael A. Ohliger¹, John Kurhanewicz¹, Daniel B. Vigneron¹, and Matthew E. Merritt⁴

¹Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States, ²GE Healthcare, San Francisco, CA, United States, ³Berkshire Magnetics, Berkeley, CA, United States, ⁴Department of Biochemistry, University of Florida, Gainesville, Gainesville, FL, United States

The purpose of this study was to investigate the feasibility of in vivo ¹³C->¹H hyperpolarization transfer, which has significant potential advantages for detecting the distribution and metabolism of hyperpolarized ¹³C probes, in a clinical MRI scanner. A standalone pulsed ¹³C RF transmit channel was developed for operation in conjunction with the standard ¹H channel of a clinical 3T MRI scanner. Operation of the custom pulsed ¹³C RF channel resulted in effective ¹³C->¹H hyperpolarization transfer, as confirmed by the characteristic anti-phase appearance of ¹H-detected, ¹J_CH-coupled doublets. ¹H detection of HP [2-¹³C]lactate generated in vivo was achieved in a rat liver slice.

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