Abstract #3052

Application of a novel 13C hyperpolarized metabolic tracer for γ-Glutamyl transferase activity in vivo tumor xenograft

Tomohiro Seki¹, Marino Itoda², Shun Kishimoto¹, Kazu Yamamoto¹, Yoichi Takakusagi³, Jeffery Brender¹, Ronja M. Malinowski⁴, Tatsuya Nishihara², Hikari A. I. Yoshihara⁵, Hiroshi Nonaka², Keita Saito¹, Nobu Oshima¹, Jan H. Ardenkjaer-Larsen⁴, James B. Mitchell¹, Murali C. Krishna¹, and Shinsuke Sando²

¹Radiation Biology Branch, CCR, NCI, NIH, Bethesda, MD, United States, ²Department of Chemistry and Biotechnology, Graduate School of Engineering, UT, Bunkyo-ku, Tokyo, Japan, ³Department of Molecular Imaging & Theranostics, QST, Chiba-shi, Japan, ⁴Electrical Engineering, Department of Electrical Engineering, DTU, Lyngby, Denmark, ⁵Institute of Physics of Biological Systems, EPFL, Lausanne, Swaziland

This research aimed to develop the non-invasive in vivo detection of γ-glutamyl transferase (GGT) activity by a novel GGT molecular probe, γ-Glu-[1-¹³C]Gly, in combination with hyperpolarized (HP) ¹³C Magnetic Resonance (MR) spectroscopy. We succeed in detecting the strong HP ¹³C MR signal of γ-Glu-[1-¹³C]Gly from tumor xenograft in vivo. Detecting HP ¹³C MR signal from the metabolite of this novel probe in tumor xenograft is our next challenge.

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