Abstract #3043

Improved Sensitivity of Cellular MRI Using Phase-cycled Balanced SSFP of Ferumoxytol Nanocomplex Labeled Macrophages at Ultra-high Field

Yelong Shen^1,2, Lirong Yan¹, Xingfeng Shao¹, Bin Zhao², Jinlun Bai³, Wange Lu³, and Danny JJ Wang¹

¹Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, United States, ²Shandong Medical Imaging Research Institute, School of Medicine, Shandong University, Jinan, China, ³Broad Stem Cell Institute, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, United States

This study aimed to investigate the feasibility and sensitivity of cellular MRI with ferumoxytol nanocomplex labeled macrophages at ultrahigh magnetic field of 7T. Different labeling strategies, labeling times, magnetic field strengths, imaging sequences and post processing methods were evaluated to achieve the optimal protocol. Combining ferumoxytol, heparin and protamine (HFP nanocomplex) labeled macrophages with balanced steady-state free precession (bSSFP) sequence on a 7T MRI scanner and post processed by root mean square (RMS) combination of multiple phases showed the best contrast in phantom and ex vivo experiments, reaching a sensitivity for detecting a few tens of cells.

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