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Abstract #3030

PET/MR Platform for Neuroscience in Awake Behaving Non-Human Primates

Rasmus Birn1, Samuel Anthony Hurley2,3, Abigail Z Rajala2, Caitlynn N Filla2, Austin M Patrick4, Dillon J Gwozdz2, Walter F Block4,5, Andrew L Alexander1,4,6, Alexander K Converse6, Rick L Jenison7, Bradley T Christian4, Alan B McMillan3, and Luis C Populin2

1Psychiatry, University of Wisconsin, Madison, WI, United States, 2Neuroscience, University of Wisconsin, Madison, WI, United States, 3Radiology, University of Wisconsin, Madison, WI, United States, 4Medical Physics, University of Wisconsin, Madison, WI, United States, 5Biomedical Engineering, University of Wisconsin, Madison, WI, United States, 6Waisman Center, University of Wisconsin, Madison, WI, United States, 7Psychology, University of Wisconsin, Madison, WI, United States

Higher-order cognitive functions result from dynamic interactions of distributed networks comprised of anatomically, physiologically, and pharmacologically separate components of the nervous system. To further our understanding the basic mechanisms and functions of such networks, as well as how they are affected by the administration of therapeutic drugs, we have developed a PET-fMRI platform to take simultaneous measurements of neural activity (fMRI), and concentration of dopamine (PET) during the same physiological state, and without the confounding effects of anesthetics. With this platform, we have measured for the first time in a primate brain the effects of administering different doses of methylphenidate on extracellular levels of dopamine and functional connectivity.

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Abstract