Abstract #3028

Truly simultaneous preclinical PET-MRI in a 20cm 9.4 Tesla magnet with a retrofitted miniature detector: Initial results in the twitcher mouse model of Krabbe disease

Ferdinand Schweser^1,2, Akshay V Dhamankar¹, Poonam Choudhary^1,3, Nadav Weinstock^4,5, Cheryl Knapp², Marilena Preda^1,2, Daesung Shin^4,5, Robert Zivadinov^1,2, and Lawrence Wrabetz^4,5,6

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³Department of Medical Physics, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁴Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁵Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁶Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

While the potential of PET-MRI is increasingly being explored in the clinical setting, preclinical PET-MRI is only slowly leaving the proof-of-concept stage, which may be explained by technical difficulties due to the size-constraints and strong magnetic fields used in preclinical MRI. In the current work, we present results from a first in vivo application of ¹⁸F-FDG PET-MRI using a retrofitted micro-PET detector in a commercial 9.4T magnet. We studied the twitcher mouse model of Krabbe disease, in which an altered glucose metabolism had been suggested.

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