Abstract #2958

Global and segmental cardiac magnetic resonance tissue tracking of hypertrophic cardiomyopathy: How does hypertrophy and fibrosis contribute to myocardial deformation?

Ruo-yang Shi¹, Bing-hua Chen¹, Dong-aolei An¹, Rui Wu¹, Liang Du², Jiani Hu³, Meng Jiang⁴, Wei-bo Chen⁵, Lian-ming Wu¹, and Jian-rong Xu¹

¹Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ²Robotics Institute, Shanghai Jiao Tong University, Shanghai, China, ³Department of Radiology, Wayne State University, Detroit, MI, United States, ⁴Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ⁵Philips Healthcare, Shanghai, China

In the patients with HCM, subtle LV deformation can be observed and measured clinically before the onset of general LV functional changes. Both hypertrophy and fibrosis influenced the extent of LV deformation. Our study demonstrated the 2D CS as a stable global parameter to assess LV functional and ECV changes. At the segmental level, hypertrophy and LGE (+) antagonistic affected 2D RS and diastolic RSR. Despite the excitement surrounding these pertinent clinical findings, further research is warranted as the mechanism of the phenomenon still needs to be explored.

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