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Abstract #2935

Local Pulse Wave Velocity from 4D-Flow MR applied in Familial Hypercholesterolemia patients.

Joaquin Mura1, Julio Sotelo1,2, Animesh Tandon3,4, Tarique Hussain3,4, Andrew Tran3,4, Cristian Tejos1,2,5, and Sergio Uribe1,5,6

1Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile, 2Electrical Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile, 3Radiology, University of Texas Southwestern, Dallas, TX, United States, 4Biomedical Engineering, University of Texas Southwestern, Dallas, TX, United States, 5Institute for Biological and Medical Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile, 6Radiology, Pontificia Universidad Catolica de Chile, Santiago, Chile

We propose an improved methodology1 to automatically estimate local 3D Pulse Wave Velocity (PWV) measurements for quantifying local alterations due to aortic distensibility using 4D flow data. 18 volunteers and 25 patients with Familial Hypercholesterolemia (FH) were evaluated using the proposed method. The results show the prevalence of higher values of PWV in FH patients than volunteers, particularly in the ascending aorta (AAo) and proximal descending aorta (pDAo). This semi-automatic 3D method is less user dependent and uses multiple correlations to improve accuracy. We demonstrate an excellent agreement with expect values.

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