Abstract #2924

A combined 4D Flow MRI-modelling approach for assessing the subject-specific effects of dobutamine on left ventricular function

Belen Casas^1,2, Federica Viola¹, Gunnar Cedersund³, Ann F Bolger⁴, Matts Karlsson^2,5, Carl-Johan Carlhäll^1,2, and Tino Ebbers^1,2

¹Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, ²Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ³Department of Biomedical Engineering, Linköping University, Linköping, Sweden, ⁴Department of Medicine, University of California San Francisco, San Francisco, CA, United States, ⁵Department of Management and Engineering, Linköping University, Linköping, Sweden

This study applies a previously developed imaging-modelling approach to investigate the subject-specific effects of dobutamine on left ventricular contraction and relaxation patterns in healthy subjects. We created personalized models for nine subjects at rest and under dobutamine stress. The personalized parameter values were in agreement with the effects of inotropy and lusitropy reported in previous studies, and demostrated the anticipated variability in individual responses to dobutamine. With further validation, the given approach has the potential to generate advanced metrics of cardiovascular physiology and pathophysiology that could extend beyond conventional techniques for both diagnosis and optimization of a personalized medical regimen.

This abstract and the presentation materials are available to members only; a login is required.

Join Here