Abstract #2909

Assessing myocardial infarct in lymphatic insufficient mice by rotating frame relaxation times

Elias Yla-Herttuala¹, Taina Vuorio¹, Johanna Laakkonen¹, Svetlana Laidinen¹, Seppo Yla-Herttuala¹, and Timo Liimatainen^1,2

¹A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland, ²Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland

Relaxation times T₂, T_1ρ and RAFFn were applied to study alterations in myocardial infarct (MI) in control and in mice with insufficient lymphatic system (VEGFR3). The findings are supported by cardiac functional parameters and histology. We found significant difference between VEGFR3 and control in T_RAFF4 (p<0.05) 8 days after MI and between pre-MI and post-MI time points in T₂ (p<0.01). Relaxation times increased significantly (p<0.05) after MI in all measurements. We conclude that T_RAFF4 gain information of alterations of fibrosis in lymphatic insufficiency after MI.

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