Correction for the amplitude of B1 (RF pulse) in CEST experiments is currently done using calibration curves fitted ad hoc with polynomial functions. We have previously found that these polynomial-based correction curves sometimes produce unreasonable results, especially in measurements with large B1 variation. Here, we use Bloch-McConnell simulations of CEST as a function of B1 strength to demonstrate a new, Lorentzian-type functional form and fitting strategy, expected to lead to an increase in both accuracy and precision in processing of CEST data.
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