Abstract #2836

Segmentation of Gray Matter, White Matter and Cerebrospinal Fluid with MP2RAGE

Yishi Wang¹, Yajie Wang¹, Zhe Zhang¹, Yuhui Xiong¹, Qiang Zhang¹, Chun Yuan^1,2, and Hua Guo¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, United States

Segmentation of gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) is an important tool for brain MRI research. A few challenges remain for the segmentation such as the image intensity non-uniformity induced by B₁ field inhomogeneity, suboptimal data acquisition protocols and long processing time. We propose a fast automatic method which combines the data acquisition with segmentation and is insensitive to B₁ field inhomogeneity using MP2RAGE. The proposed method has high accuracy and superior performance for the segmentation of subcortical gray matter and is applicable for a wide age range.

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