Abstract #2828

Quantification of liver function by linearization of a 2-compartment model of gadoxetic-acid uptake using dynamic contrast enhanced magnetic resonance imaging

Josiah Simeth^1,2, Adam Johansson², Dawn Owen², Kyle Cuneo², Michelle Mierzwa², Theodore Lawrence², Mary Feng^2,3, and Yue Cao^1,2,4

¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ²Radiation Oncology, University of Michigan, Ann Arbor, MI, United States, ³Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, ⁴Radiology, University of Michigan, Ann Arbor, MI, United States

This study used the uptake of gadoxetic acid contrast into the hepatocytes as a means of quantifying liver function. A linearized form of the dual-input two-compartment model was developed to estimate the uptake robustly and efficiently. Validation was obtained relative to the predictions of the accepted dual-input two-compartment model, and independent measurements of whole liver function. The linearized approach allows the creation of a spatially resolved quantitative image of liver function, using standard clinical acquisitions, and removes the requirement for impractical, high temporal resolution scans.

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