In this work, multivariate response-driven lateralization models were developed using MRI, DTI, and SPECT attributes and logistic regression, to determine the side of epileptogenicity in TLE patients. The proposed response models were capable of handling missing data points using imputation of missing attributes by their mean values measured on a control cohort. Additionally, the proposed response model can be further generalized by integrating attributes of additional modalities (such as PET- positron emission tomography) into the process. Increased reliability in lateralizing TLE cases using the proposed response model reinforces the notion that ECoG in a number of cases may be circumvented.
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