We introduce a new 3D GRE acquisition strategy to greatly improve the SNR efficiency of quantitative 3D T1ρ mapping. Unlike the state-of-the-art 3D MAPSS method, the proposed approach assigns a unique variable flip angle schedule for each spin-lock preparation pulse duration. This enables the use of larger flip angles and greater flexibility in selection of imaging parameters to improve SNR efficiency. In this work, we evaluate this technique for T1ρ mapping of the brain, but this method can also be applied to other regions of the body and used with a variety of magnetization preparation pulses.
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