Asymmetric Spin Echo (ASE) MRI has been previously applied for quantitative cerebral oxygen extraction mapping. In this study we optimize this technique using O-15 PET as a gold standard for oxygen extraction fraction (OEF) quantitation and apply the optimized ASE approach for studying brain lesions in Moya-Moya patients. Results suggest that optimized OEF maps from ASE MRI have the potential to detect brain lesions unseen with conventional MRI sequences. These lesions detected by ASE appear to provide information that is statistically independent from the information provided by conventional MRI approaches.
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