Abstract #2617

Diffusion MRI alteration following the induction of mild liver fibrosis in a rabbit model

Matteo Figini¹, Liang Pan^1,2, Chong Sun^1,3, Bin Wang^1,4, Junjie Shangguan¹, Kang Zhou^1,5, Na Shang¹, Quanhong Ma¹, and Zhuoli Zhang¹

¹Radiology, Northwestern University, Chicago, IL, United States, ²Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China, ³Orthopedics, Qilu Hospital, Shandong University, Jinan, China, ⁴General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁵Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

Nine rabbits were injected with carbon tetrachloride for 6 weeks to induce liver fibrosis. At the end of this period, these rabbits and 15 controls injected with saline underwent an imaging protocol including diffusion MRI. Histology showed mild fibrosis throughout the liver of the CCl4-injected animals. The Apparent Diffusion Coefficient in the liver of the fibrotic rabbits was significantly higher than in the controls. This counterintuitive result can be explained by the presence of many conflicting mechanisms during the early stage of fibrosis. If confirmed, the ADC could become a valuable tool for the early detection of liver fibrosis .

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