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Abstract #2601

Gradient-Echo MRI for Liver Iron Content Determination employing R2* Relaxometry: Influence of Gender and Disease

Arthur Peter Wunderlich1,2, Sabrina Schweyer1, Daniel Frisch1, Justin Brosig1, Holger Cario3, Meinrad Beer1, and Stefan Andreas Schmidt1

1Diagnostic and Interventional Radiology, University Ulm, Medical Center, Ulm, Germany, 2Section for Experimental Radiology, University Ulm, Medical Center, Ulm, Germany, 3Department of Pediatrics and Adolescent Medicine, University Ulm, Medical Center, Ulm, Germany

To investigate the relation between R2* gained from gradient echo (GRE) MRI and liver iron concentration (LIC), we studied the influence of patient characteristics. 205 patients (92 f, 113 m; 98 with Thalassemia major, 31 with Sickle Cell Anemia, 15 with Diamond-Blackfan-Anemia) suspected for liver iron overload were scanned according to Ferriscan® with spin echo MRI to obtain reference LIC values, and GRE protocols suitable for LIC determination. GRE analysis based on manually drawn liver ROIs and relaxometry yielded R2* values. Correlation analysis of R2* to reference LIC revealed different correlation parameters between patient subgroups concerning disease and gender.

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