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Abstract #2597

Inter-method Reproducibility of Biexponential R2 Magnetic Resonance Relaxometry for Estimation of Liver Iron Concentration

Ali Pirasteh1, Qing Yuan1, Ivan Pedrosa2, Diego Hernando3, Scott B. Reeder4, and Takeshi Yokoo1

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiology, Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Radiology, Medical Physics, University of Wisconsin, Madison, WI, United States, 4Radiology, Medical Physics, Biomedical Engineering, Medicine, Emergency Medicine, University of Wisconsin, Madison, WI, United States

Non-invasive estimation of liver iron concentration (LIC) by R2-MRI is often used for detection, grading and treatment monitoring in patients with suspected or known iron overload. The only current R2-MRI LIC estimation method with regulatory clearance is FerriScan®, a proprietary analysis for biexponential R2-relaxometry. We implemented a nonproprietary biexponential R2-relaxometry using a "dictionary-search" algorithm, to reproduce the FerriScan® results. In 38 patients with known or suspected iron overload, we demonstrated excellent reproducibility (by linearity and absolute agreement) in R2 and LIC between FerriScan® and dictionary-search analyses, suggesting generalizability of the R2-MRI approach for LIC estimation.

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