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Abstract #2581

Validation of goose liver fat measurement by CSE-MRI with biochemical extraction as reference

Li Xu1, Yangyang Duanmu1, Xiaoqi Wang2, Glen M Blake3, Peng Wang4, Manling Zhang5, Chao Wang6, and Xiaoguang Cheng1

1Department of Radiology, Beijing Jishuitan Hospital, Beijing, China, 2Philips Healthcare, Beijing, China, 3Biomedical Engineering Department, King’s College London, London, United Kingdom, 4Department of Pathology, Capital Medical University Affiliated Beijing Ditan Hospital, Beijing, China, 5China national food & safety supervision and inspection center, Beijing, China, 6Department of Statistics, Beijing Jishuitan Hospital, Beijing, China

This study aimed to validate chemical shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis. Twenty-two geese with a wide range of hepatic steatosis were collected, and proton density fat fraction by MRI (MRI-PDFF), biochemical triglyceride content, and histology were performed within the left lobe, upper and lower half of the right lobe of the geese livers. MRI correlated highly with chemical extraction (r = 0.949 (p ＜ 0.001)). Chemically extracted triglyceride was accurately predicted by MRI-PDFF (Y = -1.8 + 0.773﹡X). In conclusion, CSE-MRI measurement of goose liver fat was accurate and reliable compared with biochemical measurement.

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Abstract