Abstract #2575

Voxel Level Radiologic–Pathologic Validation of DCE-MRI with ISUP Grade in Prostate Cancer

Qing Zhang¹, Xiaoyu Lv¹, Chengwei Zhang¹, Qinglei Zhang², Ming Li², Yao Fu³, Jun Xie⁴, Jiangfen Wu⁵, Bing Zhang², and Hongqian Guo¹

¹Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, China, ²Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, ³Department of Pathology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, ⁴United Imaging Healthcare Co., Ltd, Shanghai, China, ⁵GE Healthcare, Nanjing, China

The biggest challenge in patients with newly diagnosed PCa is shifting from cancer detection or staging alone to identifying them with aggressive disease. The PI-RADS v 2 recognizes the role of DCE-MRI is limited but is essential. This work presented a radiology pathology correlation framework that enabled identification of promising in vivo DCE MRI markers of PCa risk at voxel level. The relationship between ISUP grade and DCE-MRI (Ktrans and Kep) suggests that it may be used as a component of active surveillance to noninvasively detect high-grade PCa and affect staging and treatment.

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