Abstract #2561

Multi-parametric MRI evaluation of prostate cancer volume: correlation with whole mount pathology

Chongpeng Sun^1,2, Aritrick Chatterjee¹, Ambereen Yousuf¹, Tatiana Antic³, Scott Eggener⁴, Gregory Karczmar¹, and Aytekin Oto¹

¹Department of Radiology, University of Chicago, Chicago, IL, United States, ²Department of Radiology, Guangzhou Medical University, Guangzhou, China, ³Department of Pathology, University of Chicago, Chicago, IL, United States, ⁴Department of Urology, University of Chicago, Chicago, IL, United States

This study compared prostate cancer volume determined on different multi-parametric MRI sequences: T2W imaging, ADC map and DCE-MRI with whole mount pathology in 17 patients. Tumor volumes were measured on T2W images, ADC maps and DCE-MRI by 2 radiologists and compared with reference standard volume measured from pathology. While lesion volume estimated using mpMRI sequences showed good correlation with pathology, T2W and ADC significantly underestimated, whereas DCE-MRI showed no significant difference. Therefore, DCE-MRI is the most effective sequence for estimating PCa volume with the highest accuracy compared to T2W-imaging and ADC maps and has similar good correlation and precision.

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