Abstract #2553

Optimization of the Contrast-to-noise Ratio between Malignant and Non-malignant Prostate Tissue in T2-weighted MRI.

Shirin Sabouri¹, Silvia D. Chang², Edward C. Jones³, S. Larry Goldenberg ⁴, Peter C. Black⁴, and Piotr Kozlowski²

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²Radiology, University of British Columbia, Vancouver, BC, Canada, ³Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁴Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

T2W imaging is an important sequence in the PIRADSv2 guideline for scoring prostatic lesions. The apparent contrast between malignant and non-malignant tissues on T2W images depends on the time of echo (TE). In this study we have investigated the effect of TE on the contrast-to-noise ratio (CNR) between malignant and non-malignant tissues. We have acquired and analyzed T2W data from 12 patients. Our results show that CNR increases abruptly for TEs between 25 and 175ms. After CNR reaches its maximum at 175ms it gradually decreases. Our findings may be used toward improvement of T2W protocols for diagnosis of prostatic carcinoma.

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