Abstract #2544

The Effects of Helical Flow Patterns, Confluence Angle, and Flow Distribution in the Portal Vein

David Richard Rutkowski^1,2, Scott B Reeder^2,3,4,5,6, and Alejandro Roldán-Alzate^1,2,4

¹Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

The hemodynamics of the liver in normal and diseased conditions are not fully understood. In this study, 4D flow MRI and computational modeling were used to analyze the effects of portal venous flow patterns at the spleno-mesenteric confluence. Specifically, the geometric configuration of the confluence on intra-hepatic portal circulation in healthy subjects and cirrhotic patients before and after a meal challenge was analyzed. Significant correlations between flow distribution, helicity, geometry, and flow patterns were observed, and differences between normal and pathological flow were also characterized.

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