Abstract #2473

Mapping of Ventilation/Perfusion Ratios in the human lung using 19F MRI of Perfluoropropane

Arnd Obert^1,2, Marcel Gutberlet^1,2, Alexander Rotärmel^1,2, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany

In this work, the correlation between longitudinal relaxation time (T₁), alveolar partial pressure and ventilation-perfusion ratio (V/Q) of an inhaled fluorinated gas is used to compute quantitative V/Q maps of the human lung. The trapping of inert Perfluoropropane (C₃F₈) in poorly ventilated regions of the lung (low V/Q) leads to an increase of its alveolar partial pressure which is detectable as an increase of T₁ in ¹⁹F MR Imaging. Here, V/Q maps of three patients with Chronic Obstructed Pulmonary Disease (COPD) were calculated and compared to a V/Q map of a healthy volunteer.

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