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Abstract #2456

Effects of Neonatal Lung Abnormalities on Parenchymal R2* Estimates

Andrew David Hahn1, Nara Higano2,3, Jean Tkach4, Laura Walkup2, Robert Thomen5, Xuefeng Cao2,6, Stephanie Merhar7, Paul Kingma7, Jason Woods2,3, and Sean Fain1

1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3Physics, Washington University in St. Louis, St. Louis, MO, United States, 4Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 5Radiology, University of Missouri, Columbia, MO, United States, 6Physics, University of Cincinnati, Cincinnati, OH, United States, 7Perinatal Institute, Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

We estimate pulmonary tissue densities (TD) and R2* in neonatal intensive care unit patients with and without diagnoses of lung disease as well as in healthy adults using multi-echo 3D ultrashort echo time MRI. As anticipated, a clear negative relationship between TD and R2* is evident. However, after correcting for TD variation, we find significant differences in R2* between diseased and non-diseased neonates, suggesting that MRI can probe differences in susceptibility and/or sub-voxel tissue geometry which may increase understanding of neonatal lung tissue pathologies.

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