Abstract #2448

Non-rigid motion correction for arterial spin labeled (ASL) perfusion imaging of the placenta using ANTs

Zhengjun Li¹, Eileen Hwuang¹, Jeffrey Duda², Marta Vidorretta¹, Nadav Schwartz³, John Detre^1,2, Walter Witschey², and Dylan Tisdall²

¹Dept. of Neurology, University of Pennsylvania, Philadelphia, PA, United States, ²Dept. of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Dept. of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, United States

Non-rigid motion of the placenta due to maternal breathing and fetal movement is one of the main challenges in placental MRI. In this study, we evaluated non-rigid motion correction of the placenta during arterial spin labeled (ASL) perfusion imaging, using Advanced Normalization Tools (ANTs). The results showed that non-rigid motion correction with ANTs improved the resulting perfusion images as evidenced by reduced the residual power of control-label regression, increased the tSNR, and reduced the power of respiration in the signal.

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