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Abstract #2370

BOLD activation pattern of dominant versus non-dominant hand wrist extension task in stroke patients and healthy subjects

Dixit Sharma 1, Neha Singh 1, Megha Saini 2, Sneh Anand 1, Nand Kumar 3, MV Padma Srivastava 4, S Senthil Kumaran 5, and Amit Mehndiratta1

1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Department of Biomedical Engineering, All India Institute of Medical Sciences, NEw Delhi, India, 3Department of Psychiatry, All India Institute of Medical Sciences, NEw Delhi, India, 4Department of Neurology, All India Institute of Medical Sciences, NEw Delhi, India, 5Department of Nuclear Magnetic Resonance, All India Institute of Medical Sciences, NEw Delhi, India

Flexor-hypertonia being the most common symptom of stroke, overcoming it by attaining wrist-extension can be judged as key function of recovery of stroke. We compared activation pattern of dominant versus non-dominant hand movements of wrist-extension of 6 healthy-subjects with 6 dominant and 6 non-dominant stroke using fMRI. Results in healthy-subjects show differences in activation-pattern of dominant and non-dominant hand. Stroke patient’s results shows ipsilesional activation-pattern with dominant-hemisphere stroke with activation in motor, sensory area and cerebellum as compared to no ipsilesional activation-pattern in non-dominant hemisphere stroke. These results might have further implication in structuring rehabilitation-protocol for different hemisphere stroke differently.

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Abstract