Abstract #2364

Linear systems analysis of laminar sub-millimetre GE-EPI fMRI

Jelle A van Dijk^1,2, Alessio Fracasso^1,2,3, and Serge O Dumoulin^1,2,4

¹Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, ²Experimental Psychology, Utrecht University, Utrecht, Netherlands, ³Radiology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁴Applied and Experimental Psychology, VU University, Amsterdam, Netherlands

Nearly all fMRI analysis methods assume a linear relationship between local neuronal activity and the BOLD signal. This assumption is supported for fMRI at conventional resolutions (>1 mm isotropic). We assess whether linearity of the BOLD signal holds at sub-millimetre resolution, over cortical depth. We acquired functional GE 3D-EPI data at 0.7 mm isotropic resolution (TR/TE = 57/28 ms). Stimuli consisted of moving circular sine gratings at 80%, 20%, and 5% contrast. Our results suggest that response profiles for one contrast are linearly scaled response profiles of any other contrast.

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