Paradigm design in the functional MRI acquisition is of paramount importance to investigate brain activities non-invasively. This is the first time to introduce imagination tasks of walking on floors with different surface stiffness in studying the consequence of a disease associated with diabetic peripheral neuropathy. Our results from the study-specific paradigms show a strong involvement of central nervous system in diabetic peripheral neuropathy subjects as well as cognitive deficits in sensation as caused by the disease.
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